伴有t(11;16)(q23;p13.3)且谱系转换为急性单核细胞白血病的婴儿急性淋巴细胞白血病。
Infant acute lymphoblastic leukemia with t(11;16)(q23;p13.3) and lineage switch into acute monoblastic leukemia.
作者信息
Stasik Christopher, Ganguly Siddhartha, Cunningham Mark T, Hagemeister Stacey, Persons Diane L
机构信息
Department of Pathology and Laboratory Medicine, The University of Kansas Hospital, 3901 Rainbow Boulevard, Kansas City, KS 66100, USA.
出版信息
Cancer Genet Cytogenet. 2006 Jul 15;168(2):146-9. doi: 10.1016/j.cancergencyto.2006.02.013.
Rearrangements of the mixed-lineage leukemia (MLL) gene have been associated with a poor prognosis in infant acute lymphoblastic leukemia (ALL). Previously, MLL translocations involving the CREP-binding protein (CREBBP) gene at chromosome band 16p13.3 have primarily been reported in treatment-related acute myeloid leukemia, after chemotherapy for other primary malignancies using topoisomerase II inhibitors. We report a case of de novo infant ALL with t(11;16)(q23;p13.3). After chemotherapy, this patient developed an acute monoblastic leukemia (M5b) with retention of the t(11;16)(q23;p13.3), indicating that this is a lineage switch of the original leukemic clone. To our knowledge, these findings have not been previously reported.
混合谱系白血病（MLL）基因重排与婴儿急性淋巴细胞白血病（ALL）的不良预后相关。此前，涉及染色体16p13.3带的CREP结合蛋白（CREBBP）基因的MLL易位主要在治疗相关的急性髓系白血病中报道，这些白血病发生在使用拓扑异构酶II抑制剂治疗其他原发性恶性肿瘤之后。我们报告了一例新发的婴儿ALL，其核型为t(11;16)(q23;p13.3)。化疗后，该患者发展为急性单核细胞白血病（M5b），且保留了t(11;16)(q23;p13.3)，这表明这是原始白血病克隆的谱系转换。据我们所知，这些发现此前尚未见报道。
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