一种由热休克蛋白60 T细胞表位肽（p458）和B型脑膜炎奈瑟菌荚膜多糖组成的结合疫苗。

A conjugate vaccine composed of a heat shock protein 60 T-cell epitope peptide (p458) and Neisseria meningitidis type B capsular polysaccharide.

作者信息

Amir-Kroll Hila, Riveron Luis, Sarmiento Maria E, Sierra Gustavo, Acosta Armando, Cohen Irun R

机构信息

Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.

出版信息

Vaccine. 2006 Oct 30;24(42-43):6555-63. doi: 10.1016/j.vaccine.2006.06.019. Epub 2006 Jun 27.

DOI:10.1016/j.vaccine.2006.06.019

PMID:16843573

Abstract

Neisseria meningitidis type B is a major world-health problem. The Meningococcus type B capsular polysaccharide (MnB) is very poorly immunogenic and no vaccine to the antigen exists. Here, we conjugated the MnB to a T-cell carrier peptide (p458) derived from the self-60kDa heat shock protein molecule. The conjugate vaccine was effective in inducing long-lasting IgG antibodies to the MnB antigen in mice. The vaccine was also immunogenic when injected in PBS. Thus, the p458 carrier peptide can induce T-cell help for the switch to IgG Ab to the MnB antigen.

摘要

B 型脑膜炎奈瑟菌是一个重大的全球健康问题。B 型脑膜炎球菌的荚膜多糖（MnB）免疫原性很差，目前尚无针对该抗原的疫苗。在此，我们将 MnB 与源自自身 60kDa 热休克蛋白分子的 T 细胞载体肽（p458）偶联。该偶联疫苗在小鼠中能有效诱导针对 MnB 抗原的持久 IgG 抗体。当在 PBS 中注射时，该疫苗也具有免疫原性。因此，p458 载体肽可诱导 T 细胞辅助，促使向针对 MnB 抗原的 IgG 抗体转换。