Könen-Waisman S, Cohen A, Fridkin M, Cohen I R
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
J Infect Dis. 1999 Feb;179(2):403-13. doi: 10.1086/314590.
Healthy persons manifest a high frequency of T cells reactive to epitopes of the self 60-kDa heat-shock protein (hsp60) molecule. It was reasoned that a self hsp60 peptide, p458m, might provide T cell help for a response to the T independent capsular polysaccharide of Streptococcus pneumoniae type 4 (PS4). The conjugate vaccine (PS4-p458m) induced resistance to challenge with >300,000 times the minimal lethal dose of pneumococci. PS4 conjugated to other immunogenic carriers (tetanus toxoid, a pneumolysin peptide, and others) or a commercial pneumococcal vaccine were far less effective. The effectiveness of the PS4-p458m conjugate was associated with an increased IgG1 antibody response to PS4, with long-term memory, and with T cell responses to the p458m peptide. Thus, T cell reactivity to a self epitope in a conjugate vaccine can be mobilized to induce help for resistance to a lethal infection.
健康人表现出对自身60 kDa热休克蛋白（hsp60）分子表位具有反应性的T细胞的高频率。据推测，一种自身hsp60肽p458m可能为针对4型肺炎链球菌（PS4）的非T细胞依赖性荚膜多糖的反应提供T细胞辅助。结合疫苗（PS4-p458m）诱导出对超过最小致死剂量300,000倍肺炎球菌攻击的抵抗力。与其他免疫原性载体（破伤风类毒素、一种肺炎溶血素肽等）结合的PS4或一种商业肺炎球菌疫苗的效果要差得多。PS4-p458m结合物的有效性与对PS4的IgG1抗体反应增加、长期记忆以及对p458m肽的T细胞反应有关。因此，结合疫苗中对自身表位的T细胞反应性可被调动起来，以诱导对致死性感染的抵抗力辅助。
