An expanded and flexible form of the vacuolar ATPase membrane sector.
作者信息
Clare Daniel K, Orlova Elena V, Finbow Malcolm A, Harrison Michael A, Findlay John B C, Saibil Helen R
机构信息
School of Crystallography, Birkbeck College, University of London, Malet Street, London WC1E 7HX, United Kingdom.
出版信息
Structure. 2006 Jul;14(7):1149-56. doi: 10.1016/j.str.2006.05.014.
The vacuolar ATPase integral membrane c-ring from Nephrops norvegicus occurs in paired complexes in a double membrane. Using cryo-electron microscopy and single particle image processing of 2D crystals, we have obtained a projection structure of the c-ring of N. norvegicus. The c-ring was found to be very flexible, most likely as a result of an expanded conformation of the c subunits. This structure may support a role for the vacuolar ATPase c-rings in membrane fusion.
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