Département de Biochimie, Université de Lausanne, 1066 Epalinges, Switzerland.
J Cell Biol. 2014 Apr 14;205(1):7-9. doi: 10.1083/jcb.201403040.
Neurons fire by releasing neurotransmitters via fusion of synaptic vesicles with the plasma membrane. Fusion can be evoked by an incoming signal from a preceding neuron or can occur spontaneously. Synaptic vesicle fusion requires the formation of trans complexes between SNAREs as well as Ca(2+) ions. Wang et al. (2014. J. Cell Biol. http://dx.doi.org/jcb.201312109) now find that the Ca(2+)-binding protein Calmodulin promotes spontaneous release and SNARE complex formation via its interaction with the V0 sector of the V-ATPase.
神经元通过突触小泡与质膜融合释放神经递质来进行放电。融合可以由前一个神经元传入的信号触发，也可以自发发生。突触小泡融合需要 SNARE 之间形成跨膜复合物以及 Ca(2+) 离子。Wang 等人（2014 年，《细胞生物学杂志》，http://dx.doi.org/jcb.201312109）现在发现，Ca(2+) 结合蛋白钙调蛋白通过与 V-ATP 酶的 V0 结构域相互作用促进自发释放和 SNARE 复合物的形成。
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