Wirén M, Adrian T E, Hammarqvist F, Johansson K E, Permert J, Petersson B, Wernerman J, Larsson J
Department of Surgery, University Hospital, Linköping, Sweden.
Clin Nutr. 1995 Apr;14(2):97-104. doi: 10.1016/s0261-5614(95)80029-8.
27 patients admitted for elective abdominal surgery were allocated to receive postoperative total parenteral nutrition supplemented with glutamine (glycyl-glutamine) and tyrosine (glycyl-tyrosine) containing dipeptides (DP-Gln 20; 0.16 g glutamine/kg BW/24 h) or isonitrogenous Vamin 18 for 5 days. The aim was to evaluate safety and effects on short-life plasma proteins, nitrogen balance, 3-methylhistidine excretion and alimentary growth factors in plasma. No differences in transthyretin or retinol binding protein levels, nitrogen balance or 3-methylhistidine excretion were found in patients receiving DP-Gln 20 compared to Vamin 18. There were higher plasma levels of peptide YY in the dipeptide group 5 days after surgery (p < 0.05). A correlation between insulin levels and nitrogen balance was found only in DP-Gln 20 treated patients day 6 (r = 0.91, p < 0.01). DP-Gln 20 is a glutamine dipeptide (Gly-Gln) containing amino acid solution which is considered safe in the postoperative state in man. No beneficial effects on whole body protein metabolism were found by adding DP-Gln 20 to total parenteral nutrition.
27名因择期腹部手术入院的患者被分配接受术后全胃肠外营养，其中一组补充含有谷氨酰胺（甘氨酰谷氨酰胺）和酪氨酸（甘氨酰酪氨酸）的二肽（DP-Gln 20；0.16 g谷氨酰胺/千克体重/24小时），另一组接受等氮量的凡命18，持续5天。目的是评估其安全性以及对短期血浆蛋白、氮平衡、3-甲基组氨酸排泄和血浆中营养生长因子的影响。与接受凡命18的患者相比，接受DP-Gln 20的患者在转甲状腺素蛋白或视黄醇结合蛋白水平、氮平衡或3-甲基组氨酸排泄方面未发现差异。术后5天，二肽组的血浆肽YY水平较高（p<0.05）。仅在第6天接受DP-Gln 20治疗的患者中发现胰岛素水平与氮平衡之间存在相关性（r = 0.91，p<0.01）。DP-Gln 20是一种含谷氨酰胺二肽（甘氨酰-谷氨酰胺）的氨基酸溶液，在人体术后状态下被认为是安全的。在全胃肠外营养中添加DP-Gln 20未发现对全身蛋白质代谢有有益影响。
