Michaux Catherine, Muccioli Giulio G, Lambert Didier M, Wouters Johan
Drug Design and Discovery Center, FUNDP, 61 rue de Bruxelles, B-5000 Namur, Belgium.
Bioorg Med Chem Lett. 2006 Sep 15;16(18):4772-6. doi: 10.1016/j.bmcl.2006.06.087. Epub 2006 Jul 17.
Substituted (thio)hydantoins (2-thioxoimidazolidinones and imidazolidinediones) were reported as new potential reversible inhibitors of fatty acid amide hydrolase (FAAH). Their binding mode to FAAH was explored to rationalize their activity and give idea to design highly active inhibitors. Starting from the crystal structure of one of these molecules, docking studies provide us with rational basis for the design of new inhibitors within the thiohydantoin family.
取代（硫代）乙内酰脲（2-硫代氧代咪唑烷酮和咪唑烷二酮）被报道为脂肪酸酰胺水解酶（FAAH）新的潜在可逆抑制剂。研究了它们与FAAH的结合模式，以阐明其活性，并为设计高活性抑制剂提供思路。从这些分子之一的晶体结构出发，对接研究为硫代乙内酰脲家族新抑制剂的设计提供了合理依据。
