Suppr超能文献

脂肪酸酰胺水解酶(FAAH)抑制剂的发现和开发。

The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).

机构信息

Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey, Pines Road, La Jolla, CA 92037, USA.

出版信息

Bioorg Med Chem Lett. 2011 Aug 15;21(16):4674-85. doi: 10.1016/j.bmcl.2011.06.096. Epub 2011 Jun 28.

Abstract

A summary of the discovery and advancement of inhibitors of fatty acid amide hydrolase (FAAH) is presented.

摘要

本文概述了脂肪酸酰胺水解酶(FAAH)抑制剂的发现和进展。

相似文献

1
The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).
Bioorg Med Chem Lett. 2011 Aug 15;21(16):4674-85. doi: 10.1016/j.bmcl.2011.06.096. Epub 2011 Jun 28.
2
Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.
J Med Chem. 2008 Nov 27;51(22):7057-60. doi: 10.1021/jm801051t.
3
Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.
J Med Chem. 2008 Dec 11;51(23):7327-43. doi: 10.1021/jm800311k.
5
Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity.
Bioorg Med Chem Lett. 2012 Jan 15;22(2):901-6. doi: 10.1016/j.bmcl.2011.12.032. Epub 2011 Dec 13.
6
N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors.
J Enzyme Inhib Med Chem. 2017 Dec;32(1):513-521. doi: 10.1080/14756366.2016.1265520.
7
Discovery of Uracil Derivatives as Potent Inhibitors of Fatty Acid Amide Hydrolase.
Molecules. 2016 Feb 18;21(2):229. doi: 10.3390/molecules21020229.
8
Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).
Bioorg Med Chem. 2014 Dec 1;22(23):6694-6705. doi: 10.1016/j.bmc.2014.09.012. Epub 2014 Sep 16.
10
Discovery of Isatin-Based Carbohydrazones as Potential Dual Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase.
ChemMedChem. 2022 Jan 5;17(1):e202100559. doi: 10.1002/cmdc.202100559. Epub 2021 Nov 2.

引用本文的文献

2
The pyridazine heterocycle in molecular recognition and drug discovery.
Med Chem Res. 2023 Mar 15:1-69. doi: 10.1007/s00044-023-03035-9.
3
New synthesis of 2-aroylbenzothiazoles metal-free domino transformations of anilines, acetophenones, and elemental sulfur.
RSC Adv. 2020 May 14;10(31):18423-18433. doi: 10.1039/d0ra01750g. eCollection 2020 May 10.
6
Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors.
Bioorg Med Chem. 2021 Dec 1;51:116507. doi: 10.1016/j.bmc.2021.116507. Epub 2021 Nov 11.
7
Quality of Life and a Surveillant Endocannabinoid System.
Front Neurosci. 2021 Oct 28;15:747229. doi: 10.3389/fnins.2021.747229. eCollection 2021.
9
-Aminobenzohydrazide Derivatives as Fatty Acid Amide Hydrolase Inhibitors: Design, Synthesis and Biological Evaluation.
Iran J Pharm Res. 2020 Fall;19(4):103-112. doi: 10.22037/ijpr.2020.113899.14551.

本文引用的文献

1
Recent advances in the discovery and evaluation of fatty acid amide hydrolase inhibitors.
Expert Opin Drug Discov. 2010 Oct;5(10):961-93. doi: 10.1517/17460441.2010.513378. Epub 2010 Aug 26.
2
Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.
ACS Med Chem Lett. 2011 Feb 10;2(2):91-96. doi: 10.1021/ml100190t.
4
Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH).
Proc Natl Acad Sci U S A. 2011 May 3;108(18):7379-84. doi: 10.1073/pnas.1016167108. Epub 2011 Apr 18.
6
Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.
Bioorg Med Chem Lett. 2011 Apr 15;21(8):2492-6. doi: 10.1016/j.bmcl.2011.02.052. Epub 2011 Feb 17.
8
An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase.
J Lipid Res. 2011 Feb;52(2):337-44. doi: 10.1194/jlr.M012153. Epub 2010 Nov 19.
9
Fatty acid amide signaling molecules.
Bioorg Med Chem Lett. 2010 Oct 15;20(20):5959-68. doi: 10.1016/j.bmcl.2010.08.048. Epub 2010 Aug 13.
10
A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.
Bioorg Med Chem Lett. 2010 Aug 1;20(15):4406-11. doi: 10.1016/j.bmcl.2010.06.050. Epub 2010 Jun 15.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验