Govorin N V, Govorin A V, Skazhutin S A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1991;91(7):121-4.
Lipid peroxidation (LPO) processes and the status of the ++bio-antioxidant defence system were studied in 133 male patients with continuous paranoid schizophrenia associated with hallucinatory and paranoid symptomatology, refractory to treatment. According to the ++clinico-pathogenetic principle, 3 groups of resistant patients were made up: an "endogenous" one (because of high progression), a "pharmacogenous" one (secondary, formed in accordance with the mechanisms of "adaptation" to neuroleptics, and a "resistant" one formed on the "pathological ground". The data were compared both to the normal patients (control) and to those in patients with acute paranoid schizophrenia and in a state of a remission. All the examined patients showed activation of LPO while the patients with acute schizophrenia were marked by a dramatic increase (by 2.5 to 3 times) of the intensity of LPO as compared to normals. During formation of therapeutic resistance, all the groups, in addition to the high values of the LPO intensity, demonstrated remarkable signs of depletion of the ++bio-antioxidant defence system, particularly in the group with resistance on the "pathological ground".
对133例患有持续性偏执型精神分裂症且伴有幻觉和偏执症状、治疗无效的男性患者的脂质过氧化（LPO）过程及生物抗氧化防御系统状态进行了研究。根据临床病理发生学原理，将耐药患者分为3组：“内源性”组（因病情进展迅速）、“药源性”组（继发性，根据对神经阻滞剂的“适应”机制形成）和“耐药性”组（在“病理基础”上形成）。将这些数据与正常患者（对照组）以及急性偏执型精神分裂症患者和缓解期患者的数据进行了比较。所有接受检查的患者均表现出LPO激活，而急性精神分裂症患者的LPO强度与正常人相比显著增加（增加2.5至3倍）。在形成治疗抵抗期间，所有组除了LPO强度值较高外，生物抗氧化防御系统均表现出明显的耗竭迹象，尤其是在“病理基础”上具有耐药性的组。
