Kamiya Hiroyuki, Klima Uwe, Hagl Christian, Kallenbach Klaus, Shrestha Malakh L, Khaladj Nawid, Bog Antje, Haverich Axel, Karck Matthias
Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany.
Heart Surg Forum. 2006;9(4):E759-61. doi: 10.1532/HSF98.20061032.
We have been using only moderate hypothermic circulatory arrest (HCA) for patients with ascending aortic aneurysms extending into the proximal aortic arch if the distal anastomoses seem to be simple and easy. The aim of this study is to evaluate the early and midterm results of the use of moderate HCA without any adjunctive cerebral protection in such patients.
Between October 2000 and March 2005, 23 patients with an age range of 39 to 77 years (mean, 59.7 +/- 12.2 years) received surgical repair of the ascending aorta extending into the proximal aortic arch using HCA without any adjunctive cerebral protection. Mean circulatory arrest time was 7.5 +/- 2.0 minutes (range, 2-13 minutes), and mean core temperature at induction of the circulatory arrest was 26.7 +/- 1.4 degrees C (range, 24-30 degrees C).
Operative mortality was 4.3% (1/23) due to unknown cause after successful extubation. Temporary neurological dysfunction was observed in only 1 patient (4.3%), and no persistent neurologic event was observed in any of the patients. One patient died 3 months after the operation due to a mediastinitis. No other cardiac or neurologic event was observed in the 21 surviving patients.
Our results suggest that moderate HCA at 26 degrees C to 28 degrees C without any adjunctive cerebral protection within 10 minutes is safe in selected patients.
对于升主动脉瘤累及主动脉弓近端的患者,如果远端吻合似乎简单易行,我们一直仅采用中度低温循环停止(HCA)。本研究的目的是评估在此类患者中使用中度HCA且无任何辅助脑保护措施的早期和中期结果。
2000年10月至2005年3月期间,23例年龄在39至77岁(平均59.7±12.2岁)的患者接受了使用HCA对累及主动脉弓近端的升主动脉进行手术修复,且未采取任何辅助脑保护措施。平均循环停止时间为7.5±2.0分钟(范围2 - 13分钟),循环停止诱导时的平均核心温度为26.7±1.4℃(范围24 - 30℃)。
成功拔管后,因不明原因手术死亡率为4.3%(1/23)。仅1例患者(4.3%)出现短暂性神经功能障碍,所有患者均未观察到持续性神经事件。1例患者术后3个月因纵隔炎死亡。在21例存活患者中未观察到其他心脏或神经事件。
我们的结果表明,在选定患者中,在10分钟内于26℃至28℃进行中度HCA且无任何辅助脑保护措施是安全的。