Kamiya Hiroyuki, Hagl Christian, Kropivnitskaya Irina, Weidemann Juergen, Kallenbach Klaus, Khaladj Nawid, Haverich Axel, Karck Matthias
Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany.
Ann Thorac Surg. 2007 Mar;83(3):1055-8. doi: 10.1016/j.athoracsur.2006.09.085.
The aim of this study is to evaluate the safety of proximal arch repair using only moderate hypothermic circulatory arrest (HCA) at a temperature of 25 degrees C to 28 degrees C without any adjunctive cerebral protection in comparison with those with moderate HCA and selective cerebral perfusion.
Thirty patients who underwent proximal arch repair using moderate HCA without selective cerebral perfusion (SCP) were retrospectively examined and defined as the SCP (-) group. As a control group, 31 patients who underwent moderate HCA and SCP within 10 minutes were included in this study and defined as the SCP (+) group.
Mean circulatory arrest time was 9.4 +/- 0.8 minutes and 7.5 +/- 1.8 minutes (p = 0.0001) and mean nasopharyngeal temperature at the induction of the circulatory arrest was 26.0 +/- 1.2 degrees C and 26.8 +/- 1.3 degrees C (p = 0.014) in the SCP (+) group and SCP (-) group, respectively. Operative mortality was 3.2% in the SCP (+) group and 3.3% in the SCP (-), and neurologic complications were found in three (9.7%) patients in the SCP (+) group and two (6.7%) patients in the SCP (-) group (p = 0.69).
It was possible to perform proximal arch replacement in selected patients using moderate HCA without any adjunctive cerebral protection with excellent results, and no advantage of the use of SCP was found in patients who required short HCA for proximal arch replacement.
本研究旨在评估在25摄氏度至28摄氏度的温度下仅使用中度低温循环停止(HCA)且无任何辅助脑保护措施进行近端主动脉弓修复的安全性,并与采用中度HCA和选择性脑灌注的情况进行比较。
回顾性检查30例接受无选择性脑灌注(SCP)的中度HCA近端主动脉弓修复的患者,并将其定义为SCP(-)组。作为对照组,本研究纳入31例在10分钟内接受中度HCA和SCP的患者,并将其定义为SCP(+)组。
SCP(+)组和SCP(-)组的平均循环停止时间分别为9.4±0.8分钟和7.5±1.8分钟(p = 0.0001),循环停止诱导时的平均鼻咽温度分别为26.0±1.2摄氏度和26.8±1.3摄氏度(p = 0.014)。SCP(+)组的手术死亡率为3.2%,SCP(-)组为3.3%,SCP(+)组有3例(9.7%)患者出现神经并发症,SCP(-)组有2例(6.7%)患者出现神经并发症(p = 0.69)。
对于选定的患者,在无任何辅助脑保护措施的情况下使用中度HCA进行近端主动脉弓置换是可行的,且效果良好,对于需要短时间HCA进行近端主动脉弓置换的患者,未发现使用SCP有任何优势。