Petzold A, Ottinger A, Hammer J, Walter J
Klinik für Chirurgie, Universität Leipzig, Bundesrepublik Deutschland.
Gastroenterol J. 1991;51(2):81-92.
In this study was observed the influence of Pancreozymin, Secretin, Glucagon, Pentagastrin and Somatostatin on the motility of duodenum in 256 seances in acute experiments on 12 dogs before and after truncal vagotomy and on 20 Wistar rats. As a control we used the return of the parameters of electrical and motor activity to their original levels. The reaction was registered with the help of electromyography, using bipolar electrodes and with measurement of intraluminal pressure, using open-tip catheter technique. Spike-activity was graphically presented and statistically performed. It was shown, that Secretin and Glucagon caused relaxation of duodenum, but Pentagastrin, Pancreozymin and Somatostatin stimulated duodenal motility with spastic component and gradual phasic character of a process. After truncular vagotomy the reaction to Pancreozymin and Pentagastrin was slowly, to Glucagon strongly reduced, but the reaction to Secretin was extended. We observed after TV either no reaction or a diminished reaction to Somatostatin. This study serves as experimental basis for use of gastrointestinal hormones and electromyography for diagnosis and therapy of motility disorders of duodenum in surgical practice.
在本研究中，观察了促胰液素、促胰酶素、胰高血糖素、五肽胃泌素和生长抑素对12只犬在急性实验中256次实验的十二指肠运动的影响，这些实验分别在迷走神经干切断术前、术后以及20只Wistar大鼠身上进行。作为对照，我们使用电活动和运动活动参数恢复到原始水平。反应通过肌电图记录，使用双极电极，并通过开放尖端导管技术测量腔内压力。对峰电位活动进行了图形呈现和统计学分析。结果表明，促胰液素和胰高血糖素可导致十二指肠松弛，但五肽胃泌素、促胰酶素和生长抑素刺激十二指肠运动，具有痉挛成分和过程的渐进阶段性特征。迷走神经干切断术后，对促胰酶素和五肽胃泌素的反应缓慢，对胰高血糖素的反应强烈降低，但对促胰液素的反应延长。我们观察到，迷走神经干切断术后，对生长抑素要么无反应，要么反应减弱。本研究为在外科实践中使用胃肠激素和肌电图诊断和治疗十二指肠运动障碍提供了实验依据。
