Bollina Durgaprasad, Lee Bernett T K, Tan Tin Wee, Ranganathan Shoba
Department of Chemistry and Biomolecular Sciences and Biotechnology Research Institute, Macquarie University, Sydney, NSW 2109, Australia.
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W444-7. doi: 10.1093/nar/gkl268.
Alternative transcript diversity manifests itself a prime cause of complexity in higher eukaryotes. The Alternative Splicing Graph Server (ASGS) is a web service facilitating the systematic study of alternatively spliced genes of higher eukaryotes by generating splicing graphs for the compact visual representation of transcript diversity from a single gene. Taking a set of transcripts in General Feature Format as input, ASGS identifies distinct reference and variable exons, generates a transcript splicing graph, an exon summary, splicing events classification and a single line graph to facilitate experimental analysis. This freely available web service can be accessed at http://asgs.biolinfo.org.
可变转录本多样性是高等真核生物复杂性的一个主要原因。可变剪接图谱服务器(ASGS)是一种网络服务,它通过生成剪接图谱来紧凑直观地呈现单个基因的转录本多样性,从而促进对高等真核生物可变剪接基因的系统研究。以通用特征格式的一组转录本作为输入,ASGS识别不同的参考外显子和可变外显子,生成转录本剪接图谱、外显子总结、剪接事件分类和单线条图,以方便实验分析。这个免费的网络服务可通过http://asgs.biolinfo.org访问。