Li Xiang-An, Everson William, Smart Eric J
Department of Pediatrics, University of Kentucky Medical School, Lexington, 40536, USA.
Cardiovasc Toxicol. 2006;6(1):1-13. doi: 10.1385/ct:6:1:1.
Endothelial nitric oxide synthase (eNOS) is an enzyme that plays a critical role in normal cardiovascular function. Caveolae are structures within the surface membrane of cells in which many signaling and second messenger pathways, including nitric oxide, are regulated. Many interventions in cardiovascular disease act, in part, either by changing factors that directly influence eNOS, or by changing a complex set of proteins that act indirectly on caveolae, to alter eNOS activity. In this review, we will focus on the regulation of eNOS activity by circulating factors which are altered in cardiovascular disease and the effects of pharmacological interventions that act partially through effects on eNOS.
内皮型一氧化氮合酶（eNOS）是一种在正常心血管功能中起关键作用的酶。小窝是细胞表面膜内的结构，许多信号传导和第二信使途径，包括一氧化氮，都在其中受到调节。心血管疾病中的许多干预措施部分是通过改变直接影响eNOS的因素，或通过改变一组间接作用于小窝的复杂蛋白质来改变eNOS活性。在这篇综述中，我们将重点关注心血管疾病中发生改变的循环因子对eNOS活性的调节，以及部分通过对eNOS的作用而起作用的药物干预的效果。
