Shen L, Qiao A, Ding H, Mo G, Xu G, Du Y, Li M, Chen Z, Zeng Y
Biomechanics & Medical Information Institute, Beijing University of Technology, China.
Australas Phys Eng Sci Med. 2006 Jun;29(2):196-202. doi: 10.1007/BF03178893.
In order to simulate the hemodynamic environment of human arteries in vivo, we designed a laminar flow apparatus which can precisely simulate the normal stress and shear stress to which cultured endothelial cells are exposed. Under both normal and abnormal physiological conditions, this apparatus can accurately control and adjust the values of normal stress and shear stress and the frequency of pulse waves, as well as the amplitude of pulsatile flow. This in vitro apparatus provides an experimental platform for studying the response of the biological characteristics of cultured endothelial cells in a hemodynamic environment.
为了模拟人体动脉在体内的血流动力学环境，我们设计了一种层流装置，该装置可以精确模拟培养的内皮细胞所承受的法向应力和剪切应力。在正常和异常生理条件下，该装置都能精确控制和调节法向应力、剪切应力的值以及脉搏波的频率，还有脉动流的幅度。这种体外装置为研究培养的内皮细胞在血流动力学环境中的生物学特性响应提供了一个实验平台。
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