Wu Hao, Xu Zhe, Qin Kairong, Joji Ando
Institute of Biomechanics, Department of Mechanics & Engineering Science, Fudan University, Shanghai 200433, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2007 Oct;24(5):1061-4.
The silicone tube flow chamber system has been used to study the effects of wall shear stress and circumferential stress on the cultured vascular endothelial cells (ECs). In solviong the problem of how to precisely simulate the wall shear stress and circumferential stress to which ECs are subjected under physiological conditions, it is very essential to select not only the appropriate geometrical and mechanical characteristic but also the proper preload and after-load of the silicone tube flow chamber. Firstly, a method to obtain the geometrical and mechanical characteristic of the chamber was given. Secondly, the procedure to simulate the two main mechanical stimuli under the physiological environment was proposed. Finally, the factors controlling the wall shear stress and circumferential stress were summarized.
硅胶管流动腔系统已被用于研究壁面剪应力和周向应力对培养的血管内皮细胞（ECs）的影响。在解决如何精确模拟生理条件下ECs所承受的壁面剪应力和周向应力这一问题时，不仅要选择合适的几何和力学特性，还要选择硅胶管流动腔合适的预负荷和后负荷，这是非常必要的。首先，给出了一种获取流动腔几何和力学特性的方法。其次，提出了在生理环境下模拟这两种主要力学刺激的步骤。最后，总结了控制壁面剪应力和周向应力的因素。
