Greenstein Alexander, Militscher Idan, Chen Juza, Matzkin Haim, Lessing Joseph B, Abramov Liora
Department of Urology and Sex Therapy Clinic, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
J Reprod Med. 2006 Jun;51(6):500-2.
To determine whether evaluation and treatment of hyperoxaluria in vulvar vestibulitis syndrome (VVS) is justified.
Forty women (mean age, 24.5 years; range, 18-35) diagnosed with VVS at a sex therapy clinic participated. Diagnosis of VVS relied upon Friedrich's criteria: (1) severe vulvar vestibular pain upon touch or attempted vaginal entry, (2) tenderness to pressure localized within the vulvar vestibule, and (3) physical findings confined to vulvar erythema of various degrees. Oxalate was measured in 24-hour urine samples. Women with hyperoxaluria (urine oxalate >50 mg/24 h) were placed on a low-oxalate diet and oral calcium citrate as single therapy and reevaluated 3 months later.
Hyperoxaluria was diagnosed in 7 women (17.5%), of whom 1 demonstrated an objective improvement and could have pain-free vaginal intercourse following treatment, yielding a 2.5% benefit from the evaluation and treatment of hyperoxaluria.
There is no justification for evaluation and treatment of hyperoxaluria in women with VVS due to its low yield and economic burden.
确定对外阴前庭炎综合征（VVS）患者进行高草酸尿症评估和治疗是否合理。
40名在性治疗诊所被诊断为VVS的女性（平均年龄24.5岁；范围18 - 35岁）参与了研究。VVS的诊断依据Friedrich标准：（1）触碰或尝试阴道插入时外阴前庭严重疼痛，（2）局限于外阴前庭的压痛，（3）体格检查结果仅限于不同程度的外阴红斑。对24小时尿液样本进行草酸盐检测。高草酸尿症（尿草酸盐>50 mg/24 h）的女性接受低草酸盐饮食和口服柠檬酸钙单一疗法，并在3个月后重新评估。
7名女性（17.5%）被诊断为高草酸尿症，其中1名在治疗后有客观改善且能进行无痛阴道性交，高草酸尿症评估和治疗的获益率为2.5%。
鉴于其低收益和经济负担，对VVS女性进行高草酸尿症评估和治疗没有合理依据。
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