Gebhardt Christoffer, Németh Julia, Angel Peter, Hess Jochen
Division of Signal Transduction and Growth Control, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
Biochem Pharmacol. 2006 Nov 30;72(11):1622-31. doi: 10.1016/j.bcp.2006.05.017. Epub 2006 Jul 17.
Calprotectin (S100A8/A9), a heterodimer of the two calcium-binding proteins S100A8 and S100A9, was originally discovered as immunogenic protein expressed and secreted by neutrophils. Subsequently, it has emerged as important pro-inflammatory mediator in acute and chronic inflammation. More recently, increased S100A8 and S100A9 levels were also detected in various human cancers, presenting abundant expression in neoplastic tumor cells as well as infiltrating immune cells. Although, many possible functions have been proposed for S100A8/A9, its biological role still remains to be defined. Altogether, its expression and potential cytokine-like function in inflammation and in cancer suggests that S100A8/A9 may play a key role in inflammation-associated cancer.
钙卫蛋白（S100A8/A9）是两种钙结合蛋白S100A8和S100A9的异二聚体，最初被发现是由中性粒细胞表达和分泌的免疫原性蛋白。随后，它成为急性和慢性炎症中重要的促炎介质。最近，在各种人类癌症中也检测到S100A8和S100A9水平升高，在肿瘤细胞以及浸润的免疫细胞中大量表达。尽管已经提出了S100A8/A9的许多可能功能，但其生物学作用仍有待确定。总之，其在炎症和癌症中的表达及潜在的细胞因子样功能表明，S100A8/A9可能在炎症相关癌症中起关键作用。
