Maharajan P, Quagliarotti G, Paino G, Maharajan V
CNR Istituto di Cibernetica, Napoli, Italy.
Riv Biol. 1991;84(3):315-24, 355-69.
Morphogenesis of vertebrate limb, specifically that of the chick wing, has been recognized as a suitable model to study the cellular and molecular mechanisms of pattern formation. The importance of cellular inductive phenomena and the relevance of the processes such as cell division and cell death in the above model are discussed. These studies have revealed the retinoic acid (RA) and retinols as convincing candidates for vertebrate morphogens. The recent discovery that the RA receptors belong to the steroid hormone receptor superfamily might indicate the universality of the RA morphogen and might enlighten the possible mode of its action. Identification and characterization of the 1d locus genes associated with the mouse limb morphogenesis and the possible involvement of the homeobox proteins in chick wing development have opened new prospects in understanding the molecular mechanisms of vertebrate morphogenesis.
脊椎动物肢体的形态发生，特别是鸡翅膀的形态发生，已被公认为是研究模式形成的细胞和分子机制的合适模型。讨论了细胞诱导现象的重要性以及上述模型中细胞分裂和细胞死亡等过程的相关性。这些研究表明，视黄酸（RA）和视黄醇是脊椎动物形态发生素的有力候选者。最近发现RA受体属于类固醇激素受体超家族，这可能表明RA形态发生素的普遍性，并可能揭示其作用的可能模式。与小鼠肢体形态发生相关的1d位点基因的鉴定和表征，以及同源框蛋白可能参与鸡翅膀发育，为理解脊椎动物形态发生的分子机制开辟了新的前景。
