Bohinc Klemen, Lombardo Darko, Kraljiglic Veronika, Fosnaric Miha, May Sylvio, Pernus Franjo, Hägerstrand Henry, Iglic Ales
Laboratory of Physics, Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia.
Cell Mol Biol Lett. 2006;11(1):90-101. doi: 10.2478/s11658-006-0009-3.
A theoretical model of a two-component bilayer membrane was used in order to describe the influence of anisotropic membrane inclusions on shapes of membrane daughter micro and nano vesicles. It was shown that for weakly anisotropic inclusions the stable vesicle shapes are only slightly out-of-round. In contrast, for strongly anisotropic inclusions the stable vesicle shapes may significantly differ from spheres, i.e. they have a flattened oblate shape at small numbers of inclusions in the membrane, and an elongated cigar-like prolate shape at high numbers of inclusions in the vesicle membrane.
为了描述各向异性膜内含物对膜衍生的微纳囊泡形状的影响，使用了双组分双层膜的理论模型。结果表明，对于弱各向异性内含物，稳定的囊泡形状只是略微偏离圆形。相比之下，对于强各向异性内含物，稳定的囊泡形状可能与球体有显著差异，即在膜中内含物数量较少时呈扁平的扁球形，而在囊泡膜中内含物数量较多时呈细长的雪茄状长球形。
