Tsafrir Ilan, Caspi Yaron, Guedeau-Boudeville Marie-Alice, Arzi Tamar, Stavans Joel
Department of Physics of Complex Systems, The Weizmann Institute of Science, Rehovot 76100, Israel.
Phys Rev Lett. 2003 Sep 26;91(13):138102. doi: 10.1103/PhysRevLett.91.138102. Epub 2003 Sep 25.
We studied local budding and tubulation induced in highly oblate lipid vesicles by the anchoring of either polymers having a hydrophilic backbone and grafted hydrophobic anchor groups, or by oleoyl-coenzyme A, an amphiphilic molecule important in lipid metabolism. The dynamics of bud formation, shrinkage, and readsorption is consistent with an induced spontaneous curvature coupled with local amphiphile diffusion on the membrane. We report a novel metastable state prior to bud readsorption.
我们研究了通过具有亲水性主链和接枝疏水性锚定基团的聚合物锚定，或通过油酰辅酶A（一种在脂质代谢中重要的两亲分子）在高度扁长的脂质囊泡中诱导的局部出芽和管状化。芽形成、收缩和再吸附的动力学与诱导的自发曲率以及膜上局部两亲分子扩散相一致。我们报告了芽再吸附之前的一种新型亚稳态。
