光响应性聚电解质/金纳米颗粒微胶囊

Light-responsive polyelectrolyte/gold nanoparticle microcapsules.

作者信息

Angelatos Alexandra S, Radt Benno, Caruso Frank

机构信息

Center for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.

出版信息

J Phys Chem B. 2005 Feb 24;109(7):3071-6. doi: 10.1021/jp045070x.

DOI:10.1021/jp045070x

PMID:16851322

Abstract

We report the preparation and characterization of light-responsive delivery vehicles, microcapsules composed of multiple polyelectrolyte layers and light-absorbing gold nanoparticles. The nanostructured capsules were loaded with macromolecules (fluorescein isothiocyanate-labeled dextran) by exploiting the pH-dependence of the shell permeability, and the encapsulated material was released on demand upon irradiation with short (10 ns) laser pulses in the near-infrared (1064 nm). In addition, the polyelectrolyte multilayer shell was modified with lipids (dilauroylphosphatidylethanolamine) and then functionalized with ligands (monoclonal immunoglobulin G antibodies) for the purposes of enhanced stability and targeted delivery, respectively. We anticipate that these capsules will find application in a range of areas where controlled delivery is desirable.

摘要

我们报告了光响应性递送载体的制备与表征，该载体为包含多个聚电解质层和吸光金纳米颗粒的微胶囊。利用壳层渗透性对pH的依赖性，将大分子（异硫氰酸荧光素标记的葡聚糖）载入纳米结构的胶囊中，并且在近红外（1064 nm）波段用短（10 ns）激光脉冲照射时，可按需释放被封装的材料。此外，为了分别提高稳定性和实现靶向递送，用脂质（二月桂酰磷脂酰乙醇胺）对聚电解质多层壳进行了修饰，然后用配体（单克隆免疫球蛋白G抗体）进行了功能化处理。我们预计这些胶囊将在一系列需要可控递送的领域得到应用。