Angelatos Alexandra S, Radt Benno, Caruso Frank
Center for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.
J Phys Chem B. 2005 Feb 24;109(7):3071-6. doi: 10.1021/jp045070x.
We report the preparation and characterization of light-responsive delivery vehicles, microcapsules composed of multiple polyelectrolyte layers and light-absorbing gold nanoparticles. The nanostructured capsules were loaded with macromolecules (fluorescein isothiocyanate-labeled dextran) by exploiting the pH-dependence of the shell permeability, and the encapsulated material was released on demand upon irradiation with short (10 ns) laser pulses in the near-infrared (1064 nm). In addition, the polyelectrolyte multilayer shell was modified with lipids (dilauroylphosphatidylethanolamine) and then functionalized with ligands (monoclonal immunoglobulin G antibodies) for the purposes of enhanced stability and targeted delivery, respectively. We anticipate that these capsules will find application in a range of areas where controlled delivery is desirable.
我们报告了光响应性递送载体的制备与表征，该载体为包含多个聚电解质层和吸光金纳米颗粒的微胶囊。利用壳层渗透性对pH的依赖性，将大分子（异硫氰酸荧光素标记的葡聚糖）载入纳米结构的胶囊中，并且在近红外（1064 nm）波段用短（10 ns）激光脉冲照射时，可按需释放被封装的材料。此外，为了分别提高稳定性和实现靶向递送，用脂质（二月桂酰磷脂酰乙醇胺）对聚电解质多层壳进行了修饰，然后用配体（单克隆免疫球蛋白G抗体）进行了功能化处理。我们预计这些胶囊将在一系列需要可控递送的领域得到应用。
