折叠混合磷脂单层膜时的折叠速度控制

Fold-speed control in collapsing mixed phospholipid monolayers.

作者信息

Zhang Yi, Fischer Thomas M

机构信息

Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, USA.

出版信息

J Phys Chem B. 2005 Mar 3;109(8):3442-5. doi: 10.1021/jp047364o.

DOI:10.1021/jp047364o

PMID:16851377

Abstract

Mixed monolayers of dipalmitoylphosphatidylcholine (DPPC) and dipalmitoyl-phosphatidylserine are compressed beyond their collapse pressure. Primary and secondary folds that grow perpendicular to the compression direction are observed using Brewster angle microscopy. The secondary fold velocity is measured with a fast charge-coupled device camera. We observe a reduction in secondary fold speed when increasing the mole fraction of the softer DPPC component in the monolayer. The fracture kinetics follows theoretical predictions for the fold coarsening dynamics of uniaxially stressed three-dimensional systems.

摘要

二棕榈酰磷脂酰胆碱（DPPC）和二棕榈酰磷脂酰丝氨酸的混合单层被压缩至超过其崩塌压力。使用布鲁斯特角显微镜观察到垂直于压缩方向生长的初级和次级褶皱。用快速电荷耦合器件相机测量次级褶皱速度。我们观察到，当增加单层中较软的DPPC组分的摩尔分数时，次级褶皱速度会降低。断裂动力学遵循单轴应力三维系统褶皱粗化动力学的理论预测。