Zhou Jiahong, Liu Jihua, Xia Shengqin, Wang Xuesong, Zhang Baowen
Analysis & Detecting Central, Nanjing Normal University, Nanjing, 210097, People's Republic of China.
J Phys Chem B. 2005 Oct 20;109(41):19529-35. doi: 10.1021/jp0522563.
Hypocrellin A (HA), an efficient phototherapeutic agent, can chelate with lanthanum ion to form a 1:1 complex, which exhibits enhanced 1O2 generation quantum yield, a red-shifted absorption window, greatly improved water solubility, a much lengthened triplet excited state lifetime, and an increased affinity to DNA with respect to HA. These effects in turn lead to a more potent photodamage ability on calf thymus DNA for La3+-HA than HA in both aerobic and anaerobic conditions, indicating the potential application of La3+-HA in the field of photodynamic therapy (PDT).
竹红菌甲素（HA）是一种高效的光疗剂，它能与镧离子螯合形成1:1的配合物，该配合物表现出增强的单线态氧生成量子产率、红移的吸收窗口、大大提高的水溶性、显著延长的三重态激发态寿命以及相对于HA而言对DNA的亲和力增加。这些效应进而导致在有氧和无氧条件下，La3+-HA对小牛胸腺DNA的光损伤能力比HA更强，这表明La3+-HA在光动力疗法（PDT）领域具有潜在应用价值。
