竹红菌甲素与铝离子的螯合作用及所得配合物的光动力作用研究。

Studies on the chelation of hypocrellin A with aluminium ion and the photodynamic action of the resulting complex.

作者信息

Hu Y Z, An J Y, Jiang L J

机构信息

Institute of Photographic Chemistry, Academia Sinica, Beijing, China.

出版信息

J Photochem Photobiol B. 1994 Mar;22(3):219-27. doi: 10.1016/1011-1344(93)06973-7.

DOI:10.1016/1011-1344(93)06973-7

PMID:8014754

Abstract

Hypocrellin A (HA), a perylenoquinone derivative, is an efficient phototherapeutic agent. The chelation of HA with aluminium ion (Al3+) results in the formation of a 1:1 complex (Al(3+)-HA). The probable structure for this complex has been proposed. Compared with HA, this complex has a much higher solubility in water. In addition, Al(3+)-HA preserves the 1O2-generating function of HA as demonstrated by diphenylanthracene photo-bleaching experiments. In irradiated oxygen-saturated solutions of Al(3+)-HA superoxide radical anion and hydroxyl radical are formed as verified using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) as the electron spin resonance (ESR) spin trapping agent. The production of superoxide radical anion is enhanced significantly in the presence of electron donors such as 1-benzyl-1,4-dihydronicotinamide (BNAH). These results suggest that the photodynamic action of Al(3+)-HA proceeds via both type 1 and type 2 reactions.

摘要

竹红菌素A（HA）是一种苝醌衍生物，是一种高效的光疗剂。HA与铝离子（Al3+）螯合会形成1:1的络合物（Al(3+)-HA）。已提出该络合物的可能结构。与HA相比，这种络合物在水中的溶解度要高得多。此外，如二苯基蒽光漂白实验所示，Al(3+)-HA保留了HA产生单线态氧的功能。在以5,5-二甲基-1-吡咯啉-N-氧化物（DMPO）作为电子自旋共振（ESR）自旋捕获剂的情况下，经证实，在Al(3+)-HA的辐照氧饱和溶液中会形成超氧自由基阴离子和羟基自由基。在存在电子供体如1-苄基-1,4-二氢烟酰胺（BNAH）的情况下，超氧自由基阴离子的产生会显著增强。这些结果表明，Al(3+)-HA的光动力作用通过1型和2型反应进行。