发现一种新型含硼抗真菌剂5-氟-1,3-二氢-1-羟基-2,1-苯并氧杂硼杂环戊烷（AN2690），用于潜在治疗甲癣。
Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis.
作者信息
Baker Stephen J, Zhang Yong-Kang, Akama Tsutomu, Lau Agnes, Zhou Huchen, Hernandez Vincent, Mao Weimin, Alley M R K, Sanders Virginia, Plattner Jacob J
机构信息
Anacor Pharmaceuticals Inc., 1060 East Meadow Circle, Palo Alto, California 94303, USA.
出版信息
J Med Chem. 2006 Jul 27;49(15):4447-50. doi: 10.1021/jm0603724.
PMID:16854048
Abstract
A structure-activity relationship investigation for a more efficacious therapy to treat onychomycosis, a fungal infection of the toe and fingernails, led to the discovery of a boron-containing small molecule, 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), which is currently in clinical trials for onychomycosis topical treatment.
摘要
一项针对治疗甲癣（一种脚趾甲和手指甲真菌感染）的更有效疗法的构效关系研究，导致发现了一种含硼小分子5-氟-1,3-二氢-1-羟基-2,1-苯并硼唑（AN2690），该分子目前正处于甲癣局部治疗的临床试验阶段。
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