5%他氟硼酸钾外用溶液透过指甲油后在离体人指甲上的体外疗效。
In vitro efficacy of tavaborole topical solution, 5% after penetration through nail polish on ex vivo human fingernails.
作者信息
Gupta Aditya K, Vlahovic Tracey C, Foley Kelly A, Lowe Nicole Gellings, Turner Rob, Brown Marc, Hall Steve
机构信息
a Department of Medicine , University of Toronto , Toronto , Canada.
b Mediprobe Research Inc , London , Canada.
出版信息
J Dermatolog Treat. 2018 Sep;29(6):633-636. doi: 10.1080/09546634.2017.1422078. Epub 2018 Jan 10.
BACKGROUND
Topical antifungal treatments for onychomycosis are applied to clean, unpolished nails for 48 weeks or longer. Patients often wish to mask their infection with nail polish yet there is no evidence to suggest antifungal efficacy in the presence of nail polish.
OBJECTIVE
To determine if tavaborole retains the ability to penetrate the nail plate and inhibit fungal growth in the presence of nail polish.
METHOD
Tavaborole was applied to human fingernails painted with 2 or 4 coats of nail polish, and unpainted nails in an ex vivo model. Nails were mounted on TurChub chambers seeded with Trichophyton rubrum and allowed to incubate for 7 days. Antifungal activity was assessed by measuring zones of inhibition.
RESULTS AND CONCLUSION
Tavaborole exhibited antifungal activity in all experimental groups. The zones of inhibition of T. rubrum for all experimental groups (2 or 4 coats of polish, unpolished) were greater than infected controls (polished and unpolished), p < .001. Tavaborole penetrates polished nails and kills T. rubrum in this ex vivo model.
背景
用于治疗甲癣的外用抗真菌疗法需应用于清洁、未打磨的指甲上，持续48周或更长时间。患者常希望用指甲油掩盖感染，但尚无证据表明在存在指甲油的情况下抗真菌效果如何。
目的
确定在存在指甲油的情况下，他氟康唑是否仍具有穿透甲板并抑制真菌生长的能力。
方法
在体外模型中，将他氟康唑应用于涂有2层或4层指甲油的人指甲以及未涂指甲油的指甲上。将指甲安装在接种红色毛癣菌的TurChub培养室中，孵育7天。通过测量抑菌圈评估抗真菌活性。
结果与结论
他氟康唑在所有实验组中均表现出抗真菌活性。所有实验组（涂2层或4层指甲油、未涂指甲油）对红色毛癣菌的抑菌圈均大于感染对照组（涂指甲油和未涂指甲油），p < 0.001。在该体外模型中，他氟康唑可穿透涂有指甲油的指甲并杀死红色毛癣菌。
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