某些砷拮抗剂对大鼠体内亚砷酸盐和砷酸盐的毒性、分布及排泄的影响。

Effect of some arsenic antagonists on the toxicity, distribution and excretion of arsenite and arsenate in rats.

Hilmy A M, el-Domiaty N A, Kamal M A, Mohamed M A, Abou Samra W E

Department of Zoology, Faculty of Science, Alexandria University, Egypt.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1991;99(3):357-62. doi: 10.1016/0742-8413(91)90256-s.

Abstract

Arsenite and arsenate poisoned rats were treated with either BAL (2,3-dimercapto-1-propanol), penicillamine (PA) (beta-beta dimethyl cystein) or selenium (Se) (as sodium selenite). 2. The minimal dose of each antagonist that treated arsenic-induced lethality (causing 100% survival) was the same for both arsenite and arsenate. 3. Arsenic mobilization from the tissues (blood, kidney, liver, lungs, spleen, muscles, brain, heart) and its excretion in urine and feces were higher in arsenite-intoxicated animals than in arsenate-intoxicated ones. 4. The effect of each antagonist, when injected alone, on the urinary and fecal excretion of endogenous metals (Cu, Zn, Fe, Ca and Mg) was also examined. 5. The results indicated marked differences in the relative ability of BAL, PA and Se to increase the excretion of the metals.

摘要

用二巯丙醇（BAL，2,3 - 二巯基 - 1 - 丙醇）、青霉胺（PA，β - β - 二甲基半胱氨酸）或硒（Se，亚硒酸钠形式）对砷酸盐和亚砷酸盐中毒的大鼠进行治疗。2. 对于亚砷酸盐和砷酸盐，每种拮抗剂治疗砷诱导致死率（使存活率达到100%）的最小剂量是相同的。3. 亚砷酸盐中毒动物组织（血液、肾脏、肝脏、肺、脾脏、肌肉、大脑、心脏）中的砷动员及其在尿液和粪便中的排泄量高于砷酸盐中毒动物。4. 还研究了每种拮抗剂单独注射时对内源性金属（铜、锌、铁、钙和镁）尿液和粪便排泄的影响。5. 结果表明，二巯丙醇、青霉胺和硒在增加金属排泄的相对能力上存在显著差异。