Reuber M D
Pathol Microbiol (Basel). 1975;42(1):59-65. doi: 10.1159/000162722.
Palpable subcutaneous transplants of hepatocellular carcinoma-35 appeared slightly earlier in male animals; however, the number of successful growths was no greater than that in female animals. Castration and administration of testosterone or diethylstilbestrol were performed after the transplants reached 1.0-1.5 cm in size. The carcinoma was less well differentiated histologically, had more bile pigment, grew rapidly, mestastasized sooner and killed the host quickly in castrated females given testosterone propionate. Bile was present in lung metastases. There was little difference in the growth rate in intact or castrated male or female animals. Exogenous diethylstilbestrol slowed the growth of the transplants and cause weight loss in castrated males. The weight loss was felt to be related to extensive necrosis of the carcinoma.
可触及的肝细胞癌-35皮下移植在雄性动物中出现得稍早；然而，成功生长的数量并不比雌性动物多。在移植瘤达到1.0 - 1.5厘米大小时进行去势，并给予睾酮或己烯雌酚。在给予丙酸睾酮的去势雌性动物中，癌组织的组织学分化较差，胆汁色素较多，生长迅速，转移较早，且能迅速杀死宿主。肺转移灶中存在胆汁。完整或去势的雄性或雌性动物的生长速率差异不大。外源性己烯雌酚减缓了移植瘤的生长，并导致去势雄性动物体重减轻。体重减轻被认为与癌组织的广泛坏死有关。
