Das M, Agarwal A K, Seth P K
Biochem Pharmacol. 1982 Dec 1;31(23):3927-30. doi: 10.1016/0006-2952(82)90312-4.
Our results indicate that sex hormones play an important role in the regulation of brain and hepatic GST protein during maturity. The conjugating factor GSH does not appear to be under the influence of sex hormones. These observations are of great significance in view of the possibility of continued exposure to neurotoxic chemicals like DDT and Kepone which can cause significant alterations in levels of sex hormones. A reduced GSH activity could lead to a retarded biotransformation of electrophiles and thus to an enhanced toxicity.
我们的研究结果表明，性激素在成熟期大脑和肝脏谷胱甘肽S-转移酶（GST）蛋白的调节中发挥着重要作用。结合因子谷胱甘肽（GSH）似乎不受性激素的影响。鉴于可能持续接触像滴滴涕（DDT）和开蓬这样的神经毒性化学物质，而这些物质会导致性激素水平发生显著变化，所以这些观察结果具有重要意义。谷胱甘肽活性降低可能导致亲电试剂的生物转化受阻，从而增强毒性。
