Schwarzmaier Hans-Joachim, Eickmeyer Frank, von Tempelhoff Wernholt, Fiedler Volkhard Ulrich, Niehoff Hendrik, Ulrich Slif Dagobert, Yang Qin, Ulrich Frank
Center for Medical Research, Klinikum Krefeld, University of Düsseldorf Medical School at Krefeld, Germany.
Eur J Radiol. 2006 Aug;59(2):208-15. doi: 10.1016/j.ejrad.2006.05.010. Epub 2006 Jul 18.
We investigated the survival after laser-induced interstitial thermotherapy in 16 patients suffering from recurrent glioblastoma multiforme. The concept underlying the intervention is the cytoreduction of the tumor tissue by local thermocoagulation. All patients received standard chemotherapy (temozolomide). The median overall survival time after the first relapse was 9.4 months, corresponding to a median overall survival time after laser irradiation of 6.9 months. During the study, however, the median survival after laser coagulation increased to 11.2 months. This survival time is substantially longer than those reported for the natural history (<5 months) or after chemotherapy (temozolomide: 5.4-7.1 months). We conclude that cytoreduction by laser irradiation might be a promising option for patients suffering from recurrent glioblastoma multiforme. In addition, the data indicate the presence of a substantial learning curve. Future work should optimize the therapeutic regimen and evaluate this treatment approach in controlled clinical trials.
我们调查了16例复发性多形性胶质母细胞瘤患者接受激光间质热疗后的生存期。该干预措施的基本理念是通过局部热凝来减少肿瘤组织。所有患者均接受标准化疗（替莫唑胺）。首次复发后的中位总生存期为9.4个月，激光照射后的中位总生存期为6.9个月。然而，在研究期间，激光凝固后的中位生存期增加到了11.2个月。这个生存时间明显长于自然病程报道的生存期（<5个月）或化疗后的生存期（替莫唑胺：5.4 - 7.1个月）。我们得出结论，对于复发性多形性胶质母细胞瘤患者，激光照射减瘤可能是一个有前景的选择。此外，数据表明存在显著的学习曲线。未来的工作应优化治疗方案，并在对照临床试验中评估这种治疗方法。
