Tsilibaris Virginie, Maenhaut-Michel Geneviève, Van Melderen Laurence
Laboratoire de Génétique des Procaryotes, IBMM, Université Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, 6041 Gosselies, Belgium.
Res Microbiol. 2006 Oct;157(8):701-13. doi: 10.1016/j.resmic.2006.05.004. Epub 2006 Jun 30.
The Lon ATP-dependent protease plays a major role in protein quality control. An increasing number of regulatory proteins, however, are being identified as Lon substrates, thus indicating that in addition to its housekeeping function, Lon plays an important role in regulating many biological processes in bacteria. This review presents and discusses the involvement of Lon in different aspects of bacterial physiology, including cell differentiation, sporulation, pathogenicity and survival under starvation conditions.
Lon 依赖 ATP 的蛋白酶在蛋白质质量控制中起主要作用。然而，越来越多的调节蛋白被鉴定为 Lon 的底物，这表明除了其看家功能外，Lon 在调节细菌的许多生物学过程中也起着重要作用。本综述介绍并讨论了 Lon 在细菌生理学不同方面的作用，包括细胞分化、孢子形成、致病性以及在饥饿条件下的存活。
