Laimer Klaus, Spizzo Gilbert, Gastl Guenther, Obrist Peter, Brunhuber Thomas, Fong Dominic, Barbieri Verena, Jank Siegfried, Doppler Wolfgang, Rasse Michael, Norer Burghard
Division of Maxillofacial Surgery, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria.
Oral Oncol. 2007 Feb;43(2):193-8. doi: 10.1016/j.oraloncology.2006.02.009. Epub 2006 Jul 18.
This retrospective study was designed to investigate the prognostic significance of EGFR overexpression in human oral squamous cell carcinoma on a long-term follow-up. EGFR expression was examined immunohistochemically on a tissue microarray (TMA) of paraffin embedded tissue specimens from 109 patients who underwent surgical treatment for squamous cell carcinoma of the oral cavity and oropharynx in the period between 1980 and 1997. High EGFR expression was found in 80 (73.42%) of the tumour samples. Kaplan-Meier curves showed that EGFR overexpression was significantly related to decreased overall survival (p=0.05). Multivariate analysis showed that EGFR overexpression is an independent prognostic marker in these patients (p=0.02, RR 3.6). These results confirm that EGFR overexpression is an independent prognostic marker in patients with squamous cell carcinoma of the oral cavity and oropharynx. The EGFR antigen represents an attractive target for targeted therapies with monoclonal antibodies or specific tyrosine-kinase inhibitors in these patients.
本回顾性研究旨在通过长期随访调查表皮生长因子受体（EGFR）过表达在人类口腔鳞状细胞癌中的预后意义。对1980年至1997年间接受口腔和口咽鳞状细胞癌手术治疗的109例患者的石蜡包埋组织标本组织芯片（TMA）进行免疫组化检测EGFR表达。在80例（73.42%）肿瘤样本中发现EGFR高表达。Kaplan-Meier曲线显示，EGFR过表达与总生存率降低显著相关（p=0.05）。多因素分析显示，EGFR过表达是这些患者的独立预后标志物（p=0.02，相对风险3.6）。这些结果证实，EGFR过表达是口腔和口咽鳞状细胞癌患者的独立预后标志物。EGFR抗原是这些患者使用单克隆抗体或特异性酪氨酸激酶抑制剂进行靶向治疗的一个有吸引力的靶点。
