Chen Meng, Hancock Leandria C, Lopes John M
Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, MI 48202, USA.
Biochim Biophys Acta. 2007 Mar;1771(3):310-21. doi: 10.1016/j.bbalip.2006.05.017. Epub 2006 Jun 6.
The last several years have been witness to significant developments in understanding transcriptional regulation of the yeast phospholipid structural genes. The response of most phospholipid structural genes to inositol is now understood on a mechanistic level. The roles of specific activators and repressors are also well established. The knowledge of specific regulatory factors that bind the promoters of phospholipid structural genes serves as a foundation for understanding the role of chromatin modification complexes. Collectively, these findings present a complex picture for transcriptional regulation of the phospholipid biosynthetic genes. The INO1 gene is an ideal example of the complexity of transcriptional control and continues to serve as a model for studying transcription in general. Furthermore, transcription of the regulatory genes is also subject to complex and essential regulation. In addition, databases resulting from a plethora of genome-wide studies have identified regulatory signals that control one of the essential phospholipid biosynthetic genes, PIS1. These databases also provide significant clues for other regulatory signals that may affect phospholipid biosynthesis. Here, we have tried to present a complete summary of the transcription factors and mechanisms that regulate the phospholipid biosynthetic genes.
在过去的几年里，我们见证了酵母磷脂结构基因转录调控研究的重大进展。目前，我们已经从机制层面理解了大多数磷脂结构基因对肌醇的反应。特定激活因子和抑制因子的作用也已明确。关于结合磷脂结构基因启动子的特定调控因子的知识，为理解染色质修饰复合物的作用奠定了基础。总的来说，这些发现为磷脂生物合成基因的转录调控描绘了一幅复杂的图景。INO1基因是转录控制复杂性的一个理想例子，并且仍然是研究一般转录的模型。此外，调控基因的转录也受到复杂且至关重要的调控。此外，大量全基因组研究产生的数据库已经识别出控制重要磷脂生物合成基因之一PIS1的调控信号。这些数据库还为可能影响磷脂生物合成的其他调控信号提供了重要线索。在这里，我们试图全面总结调控磷脂生物合成基因的转录因子和机制。
