Gilley Phillip M, Sharma Anu, Dorman Michael, Martin Kathryn
The University of Texas at Dallas, School of Behavioral and Brain Sciences, Callier Advanced Hearing Research Center, 1966 Inwood Rd., Dallas, TX 75206, USA.
Clin Neurophysiol. 2006 Sep;117(9):1949-56. doi: 10.1016/j.clinph.2006.05.015. Epub 2006 Jul 18.
To examine maturation of the central auditory pathways in children with language-based learning problems (LP).
Cortical auditory evoked potentials (CAEPs) recorded from 26 children with LP were compared to CAEPs recorded from 38 typical children. CAEP responses were recorded in response to a speech sound, /uh/, which was presented in a stimulus train with decreasing inter-stimulus intervals (ISIs) of 2000, 1000, 560, and 360 ms.
We identified three atypical morphological categories of CAEP responses in the LP group. Category 1 responses revealed delayed P1 latencies and absent N1/P2 components. Category 2 responses revealed typical P1 responses, but delayed N1 and P2 responses. Category 3 responses revealed generally low-amplitude CAEP responses. A fourth sub-group of LP children had normal CAEP responses.
Overall, the majority of children with LP had abnormal CAEP responses. These children fell into distinct categories based on the abnormalities in maturational patterns of their CAEP responses.
We describe a rate sensitive stimulation paradigm which may be used to identify and categorize LP children who exhibit abnormal patterns of central auditory maturation.
研究基于语言学习障碍（LP）儿童的中枢听觉通路成熟情况。
将26名LP儿童记录的皮质听觉诱发电位（CAEP）与38名正常儿童记录的CAEP进行比较。CAEP反应是在对语音/uh/的反应中记录的，该语音以刺激间隔（ISI）逐渐减小的刺激序列呈现，ISI分别为2000、1000、560和360毫秒。
我们在LP组中确定了三种非典型的CAEP反应形态类别。第1类反应显示P1潜伏期延迟且N1/P2成分缺失。第2类反应显示典型的P1反应，但N1和P2反应延迟。第3类反应显示CAEP反应幅度普遍较低。第四组LP儿童的CAEP反应正常。
总体而言，大多数LP儿童的CAEP反应异常。这些儿童根据其CAEP反应成熟模式的异常情况分为不同类别。
我们描述了一种速率敏感刺激范式，可用于识别和分类表现出中枢听觉成熟异常模式的LP儿童。
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