Isa A Y, Ward T H, West C M L, Slevin N J, Homer J J
Department of Surgery, Christie Hospital, Manchester, UK.
Br J Radiol. 2006 Oct;79(946):791-8. doi: 10.1259/bjr/17904358. Epub 2006 Jul 19.
A high level of hypoxia in solid tumours is an adverse prognostic factor for the poor outcome of cancer patients following treatment. This review describes the status of research into finding a practical method for measuring hypoxia and treating hypoxic tumours. The application of such methodology would enable the selection of head and neck cancer treatment based on an individual's tumour oxygenation status. This individualization would include the selection not only of surgery or radiotherapy, but also of novel hypoxia-modification strategies.
实体肿瘤中高度的缺氧状态是癌症患者治疗后预后不良的一个不利因素。这篇综述描述了寻找测量缺氧和治疗缺氧肿瘤的实用方法的研究现状。这种方法的应用将使头颈部癌症的治疗能够基于个体肿瘤的氧合状态来进行选择。这种个体化不仅包括手术或放疗的选择，还包括新型缺氧修正策略的选择。
