多相吸收模型最能描述丙戊酸钠缓释片的胃肠道吸收特征。 - Suppr

Suppr

超能文献

A multiphasic absorption model best characterizes gastrointestinal absorption of divalproex sodium extended-release tablets.

作者信息

Dutta Sandeep, Reed Ronald C

机构信息

Abbott Laboratories, Dept. R4PK, Bldg. AP13A, 100 Abbott Park Road, Abbott Park IL 60064-6104, USA.

出版信息

J Clin Pharmacol. 2006 Aug;46(8):952-7. doi: 10.1177/0091270006289480.

DOI:10.1177/0091270006289480

PMID:16855080

Abstract

摘要

相似文献

A multiphasic absorption model best characterizes gastrointestinal absorption of divalproex sodium extended-release tablets.多相吸收模型最能描述丙戊酸钠缓释片的胃肠道吸收特征。

J Clin Pharmacol. 2006 Aug;46(8):952-7. doi: 10.1177/0091270006289480.

Absolute bioavailability and absorption characteristics of divalproex sodium extended-release tablets in healthy volunteers.丙戊酸钠缓释片在健康志愿者中的绝对生物利用度及吸收特性

J Clin Pharmacol. 2004 Jul;44(7):737-42. doi: 10.1177/0091270004266782.

Comparative absorption profiles of divalproex sodium delayed-release versus extended-release tablets -- clinical implications.丙戊酸钠缓释片与长效释放片的比较吸收曲线——临床意义

Ann Pharmacother. 2006 Apr;40(4):619-25. doi: 10.1345/aph.1G617. Epub 2006 Mar 28.

Once-a-day controlled-release dosage form of divalproex sodium I: formulation design and in vitro/in vivo investigations.丙戊酸镁缓释一日一次剂型I：制剂设计及体内外研究

J Pharm Sci. 2003 Jun;92(6):1166-73. doi: 10.1002/jps.10385.

Every-12-hour administration of extended-release divalproex in patients with epilepsy: impact on plasma valproic acid concentrations.癫痫患者每12小时服用缓释丙戊酸/divalproex：对血浆丙戊酸浓度的影响。

Epilepsy Behav. 2006 Mar;8(2):391-6. doi: 10.1016/j.yebeh.2005.12.004.

Once-a-day extended-release dosage form of divalproex sodium III: development and validation of a Level A in vitro-in vivo correlation (IVIVC).丙戊酸镁缓释片一日一次剂型III：A级体外-体内相关性（IVIVC）的开发与验证

J Pharm Sci. 2005 Sep;94(9):1949-56. doi: 10.1002/jps.20387.

Does it really matter when a blood sample for valproic acid concentration is taken following once-daily administration of divalproex-ER?在每日一次服用丙戊酸缓释片后，采集用于测定丙戊酸浓度的血样的时间真的很重要吗？

Ther Drug Monit. 2006 Jun;28(3):413-8. doi: 10.1097/01.ftd.0000211814.12311.3f.

Predicted plasma valproic acid concentrations in patients missing and replacing a full daily dose of extended-release divalproex sodium.

Am J Health Syst Pharm. 2006 May 15;63(10):904-6. doi: 10.2146/ajhp050147.

Distinct absorption characteristics of oral formulations of valproic acid/divalproex available in the United States.美国市售丙戊酸/双丙戊酸钠口服制剂的独特吸收特性。

Epilepsy Res. 2007 Mar;73(3):275-83. doi: 10.1016/j.eplepsyres.2006.11.005. Epub 2007 Jan 8.

Effect of delayed and/or missed enteric-coated divalproex doses on valproic acid concentrations: simulation and dose replacement recommendations for the clinician.肠溶型丙戊酸二钠延迟和/或漏服剂量对丙戊酸浓度的影响：模拟分析及给临床医生的剂量替代建议

J Clin Pharm Ther. 2006 Aug;31(4):321-9. doi: 10.1111/j.1365-2710.2006.00739.x.

引用本文的文献

Population pharmacokinetics of valproic acid in pediatric patients with epilepsy: considerations for dosing spinal muscular atrophy patients.丙戊酸在癫痫儿科患者中的群体药代动力学：脊髓性肌萎缩症患者给药的考虑因素。

J Clin Pharmacol. 2012 Nov;52(11):1676-88. doi: 10.1177/0091270011428138. Epub 2011 Dec 13.

Extended-release formulations for the treatment of epilepsy.用于治疗癫痫的缓释制剂。

CNS Drugs. 2007;21(9):765-74. doi: 10.2165/00023210-200721090-00005.

Functional half-life is a meaningful descriptor of steady-state pharmacokinetics of an extended-release formulation of a rapidly cleared drug : as shown by once-daily divalproex-ER.对于快速清除药物的缓释制剂，功能半衰期是稳态药代动力学的一个有意义的描述指标：如每日一次服用丙戊酸缓释片所示。

Clin Drug Investig. 2006;26(12):681-90. doi: 10.2165/00044011-200626120-00002.

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