系统性硬化症（SSc）中雄激素和催乳素（Prl）水平：与疾病严重程度的关系。

Androgen and prolactin (Prl) levels in systemic sclerosis (SSc): relationship to disease severity.

作者信息

Mirone Luisa, Barini Angela, Barini Antonella

机构信息

U.O.C. Reumatologia--Cattedra di Reumatologia, Catholic University, Rome, Italy.

出版信息

Ann N Y Acad Sci. 2006 Jun;1069:257-62. doi: 10.1196/annals.1351.023.

DOI:10.1196/annals.1351.023

PMID:16855152

Abstract

Testosterone (T), sex hormone-binding globulin, (SHBG), dehydroepiandrosterone sulfate (DHEAS), and prolactin (Prl) serum levels were measured by electrochemiluminescense immunoassay (ECLIA) in 39 patients with systemic sclerosis (SSc) and compared with serum hormonal levels in control subjects matched for sex and reproductive status. A possible relationship with disease duration and disease severity was examined. Our data show an altered androgen and prolactin (Prl) status in SSc patients, in most cases related to disease duration and disease severity score. We can hypothesize that hormonal dysregulation is a consequence of the chronicity of the disease. The altered hormonal status could result in relative immunological hyperactivity contributing to enhance tissue damage and disease severity.

摘要

采用电化学发光免疫分析法（ECLIA）测定了39例系统性硬化症（SSc）患者血清中的睾酮（T）、性激素结合球蛋白（SHBG）、硫酸脱氢表雄酮（DHEAS）和催乳素（Prl）水平，并与性别和生殖状态相匹配的对照受试者的血清激素水平进行了比较。研究了其与疾病持续时间和疾病严重程度之间的可能关系。我们的数据显示，SSc患者的雄激素和催乳素（Prl）状态发生了改变，在大多数情况下与疾病持续时间和疾病严重程度评分有关。我们可以推测，激素失调是疾病慢性化的结果。激素状态的改变可能导致相对免疫功能亢进，从而加剧组织损伤和疾病严重程度。