Are human CETP mutations and CETP-inhibiting drugs a good or a bad deal?

作者信息

Luft Friedrich C

机构信息

Franz Volhard Clinic, HELIOS Kliniken Berlin, Medical Faculty of the Charité, Humboldt University, Wiltbergstrasse 50, 13125 Berlin-Buch, Germany.

出版信息

J Mol Med (Berl). 2006 Aug;84(8):625-7. doi: 10.1007/s00109-006-0071-3. Epub 2006 Jul 20.

DOI:10.1007/s00109-006-0071-3

PMID:16855847

Abstract

摘要

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本文引用的文献

The two novel CETP mutations Gln87X and Gln165X in a compound heterozygous state are associated with marked hyperalphalipoproteinemia and absence of significant coronary artery disease.

J Mol Med (Berl). 2006 Aug;84(8):647-50. doi: 10.1007/s00109-006-0070-4. Epub 2006 Jul 20.

HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway.

J Clin Invest. 2006 May;116(5):1435-42. doi: 10.1172/JCI27602.

Putting cholesterol in its place: apoE and reverse cholesterol transport.

J Clin Invest. 2006 May;116(5):1226-9. doi: 10.1172/JCI28632.

Increasing high-density lipoprotein cholesterol in dyslipidemia by cholesteryl ester transfer protein inhibition: an update for clinicians.

Circulation. 2005 Apr 12;111(14):1847-54. doi: 10.1161/01.CIR.0000160860.36911.BD.

Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13,677 subjects.

Circulation. 2005 Jan 25;111(3):278-87. doi: 10.1161/01.CIR.0000153341.46271.40. Epub 2005 Jan 17.

Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: a randomized phase II dose-response study.

Circulation. 2002 May 7;105(18):2159-65. doi: 10.1161/01.cir.0000015857.31889.7b.

Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels.

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