Chang Yu-Chung, Tsai Hong-Min, Lin Xi-Zhang, Chang Chia-Hao, Chuang Jen Pin
Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138, Sheng Li Road, Tainan, 70428, Taiwan.
Dig Dis Sci. 2006 Aug;51(8):1388-95. doi: 10.1007/s10620-006-9112-6. Epub 2006 Jul 20.
We sought to determine if necrosectomy can be omitted for complicated acute necrotizing pancreatitis (ANP). Since 1996, we prospectively performed retroperitoneal drainage by introducing a sump drain to the pancreatic head area via a small left flank incision without debridement and irrigation on 19 consecutive complicated ANP patients. We purposely delayed surgery until liquefaction of retroperitoneal tissue reached the left flank. Our patients had a mean Ranson's and APACHE II score of 5.9 (range, 4-8) and 20.1(range, 4-45), respectively. Sixteen available CT showed retroperitoneal liquefaction after 21.3 days (range, 14-26). Operations were delayed for 4.7 weeks (range, 1.3-9.0). No patient succumbed during this period. The indications were infected necrosis in 16 and severe abdominal pain/food intolerance in 3 patients. Average skin incision was 4.0 cm (range, 3-9). Fungi or bacteria were cultured in 15 patients (80.0%). The recovery courses were surprisingly uneventful. Oral intake began within 2.4 days (range, 1-5) and mean hospital stay (16 survivals) was 23.2 days (range, 4-120) after operation. Drains were completely removed 120.6 days (range, 60-250) later from these outpatients. One gastric perforation and one minor duodenal leak were the only procedure-related complications (10.5%). Three patients died (15.8%), although one had a healed ANP. In conclusion, this delay-until-liquefaction strategy without necrosectomy is an easy and effective treatment method.
我们试图确定对于复杂性急性坏死性胰腺炎(ANP)是否可以省略坏死组织清除术。自1996年以来,我们对19例连续性复杂性ANP患者前瞻性地经左下腹小切口将一根引流管引入胰头区域进行腹膜后引流,不进行清创和冲洗。我们特意推迟手术,直到腹膜后组织液化到达左下腹。我们的患者Ranson评分和APACHE II评分的平均值分别为5.9(范围4 - 8)和20.1(范围4 - 45)。16份可用的CT显示21.3天(范围14 - 26天)后腹膜后液化。手术推迟了4.7周(范围1.3 - 9.0周)。在此期间无患者死亡。适应证为16例感染性坏死和3例严重腹痛/不耐受食物。平均皮肤切口为4.0厘米(范围3 - 9厘米)。15例患者(80.0%)培养出真菌或细菌。恢复过程出人意料地顺利。术后2.4天(范围1 - 5天)内开始经口进食,16例存活患者的平均住院时间为23.2天(范围4 - 120天)。这些门诊患者在120.6天(范围60 - 250天)后引流管完全拔除。仅1例胃穿孔和1例轻微十二指肠渗漏是仅有的与手术相关的并发症(10.5%)。3例患者死亡(15.8%),尽管其中1例ANP已愈合。总之,这种不进行坏死组织清除术的延迟至液化策略是一种简单有效的治疗方法。