Perkins S J, Murphy R, Schmidt U, Williams C
Cochrane Database Syst Rev. 2006 Jul 19(3):CD004191. doi: 10.1002/14651858.CD004191.pub2.
Anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder (BED) and eating disorder not otherwise specified (EDNOS) are common and disabling disorders. Many patients experience difficulties accessing specialist psychological treatments. Pure self-help (PSH: self-help material only) or guided self-help (GSH: self-help material with therapist guidance), may bridge this gap.
Evaluate evidence from randomised controlled trials (RCTs) / controlled clinical trials (CCTs) for the efficacy of PSH/GSH with respect to eating disorder symptoms, compared with waiting list or placebo/attention control, other psychological or pharmacological treatments (or combinations/augmentations) in people with eating disorders.
Evaluate evidence for the efficacy of PSH/GSH regarding comorbid symptomatology and costs.
CCDANCTR-Studies and CCDANCTR-References were searched in November 2005, other electronic databases were searched, relevant journals and grey literature were checked, and personal approaches were made to authors.
Published/unpublished RCTs/CCTs evaluating PSH/GSH for any eating disorder.
Data was extracted using a customized spreadsheet. Relative Risks (RR) were calculated from dichotomous data and weighted/standardized mean differences (WMD/SMD) from continuous data, using a random effects model.
Twelve RCTs and three CCTs were identified, all focusing on BN, BED, EDNOS or combinations of these, in adults, using manual-based PSH/GSH across various settings. Primary comparisons:At end of treatment, PSH/GSH did not significantly differ from waiting list in abstinence from bingeing (RR 0.72, 95% CI 0.47 to 1.09), or purging (RR 0.86, 95% CI 0.68 to 1.08), although these treatments produced greater improvement on other eating disorder symptoms, psychiatric symptomatology and interpersonal functioning but not depression. Compared to other formal psychological therapies, PSH/GSH did not differ significantly at end of treatment or follow-up in improvement on bingeing and purging (RR 0.99, 95% CI 0.75 to 1.31), other eating disorder symptoms, level of interpersonal functioning or depression. There were no significant differences in treatment dropout. Secondary comparisons:One small study in BED found that cognitive-behavioural GSH compared to a non-specific control treatment produced significantly greater improvements in abstinence from bingeing and other eating disorder symptoms. Studies comparing PSH with GSH found no significant differences between treatment groups at end of treatment or follow-up. Comparison between different types of PSH/GSH found significant differences on eating disorder symptoms but not on bingeing/purging abstinence rates.
AUTHORS' CONCLUSIONS: PSH/GSH may have some utility as a first step in treatment and may have potential as an alternative to formal therapist-delivered psychological therapy. Future research should focus on producing large well-conducted studies of self-help treatments in eating disorders including health economic evaluations, different types and modes of delivering self-help (e.g. computerised versus manual-based) and different populations and settings.
神经性厌食症(AN)、神经性贪食症(BN)、暴饮暴食症(BED)及未特定的进食障碍(EDNOS)是常见的致残性疾病。许多患者在获得专业心理治疗方面存在困难。单纯自助(PSH:仅自助材料)或引导式自助(GSH:有治疗师指导的自助材料)可能会弥补这一差距。
评估随机对照试验(RCT)/对照临床试验(CCT)的证据,以确定与等待名单或安慰剂/注意力控制、其他心理或药物治疗(或联合/强化治疗)相比,PSH/GSH对进食障碍患者进食障碍症状的疗效。
评估PSH/GSH对共病症状及成本疗效的证据。
2005年11月检索了CCDANCTR-研究和CCDANCTR-参考文献,检索了其他电子数据库,查阅了相关期刊和灰色文献,并与作者进行了个人联系。
评估PSH/GSH对任何进食障碍的已发表/未发表的RCT/CCT。
使用定制电子表格提取数据。采用随机效应模型,从二分数据计算相对风险(RR),从连续数据计算加权/标准化均数差(WMD/SMD)。
共识别出12项RCT和3项CCT,均聚焦于成人的BN、BED、EDNOS或其组合,在不同环境中使用基于手册的PSH/GSH。主要比较:治疗结束时,PSH/GSH在停止暴饮暴食(RR 0.72,95%CI 0.47至1.09)或清除行为(RR 0.86,95%CI 0.68至1.08)方面与等待名单无显著差异,尽管这些治疗在其他进食障碍症状、精神症状和人际功能方面有更大改善,但对抑郁症状无改善。与其他正式心理治疗相比,PSH/GSH在治疗结束或随访时,在暴饮暴食和清除行为改善(RR 0.99,95%CI 0.75至1.31)、其他进食障碍症状、人际功能水平或抑郁方面无显著差异。治疗退出率无显著差异。次要比较:一项针对BED的小型研究发现,与非特异性对照治疗相比,认知行为GSH在停止暴饮暴食和其他进食障碍症状方面有显著更大改善。比较PSH与GSH的研究发现,治疗组在治疗结束或随访时无显著差异。不同类型PSH/GSH之间的比较发现,在进食障碍症状方面有显著差异,但在暴饮暴食/清除行为戒断率方面无差异。
PSH/GSH作为治疗的第一步可能有一定作用,并且有可能替代由治疗师提供的正式心理治疗。未来研究应侧重于开展大规模、精心设计的进食障碍自助治疗研究,包括卫生经济学评估、自助治疗的不同类型和方式(如计算机化与基于手册的)以及不同人群和环境。