Department of Psychiatry, University of Campania L. Vanvitelli, Naples, Italy.
Department of Psychiatry, University of Campania L. Vanvitelli, Naples, Italy.
Neurosci Biobehav Rev. 2022 Nov;142:104857. doi: 10.1016/j.neubiorev.2022.104857. Epub 2022 Sep 6.
MONTELEONE, A.M., F. Pellegrino, G. Croatto, M. Carfagno, A. Hilbert, J. Treasure, T. Wade, C. Bulik, S. Zipfel, P. Hay, U. Schmidt, G. Castellini, A. Favaro, F. Fernandez-Aranda, J. Il Shin, U. Voderholzer, V. Ricca, D. Moretti, D. Busatta, G. Abbate-Daga, F. Ciullini, G. Cascino, F. Monaco, C.U. Correll and M. Solmi. Treatment of Eating Disorders: a systematic meta-review of meta-analyses and network meta-analyses. NEUROSCI BIOBEHAV REV 21(1) XXX-XXX, 2022.- Treatment efficacy for eating disorders (EDs) is modest and guidelines differ. We summarized findings/quality of (network) meta-analyses (N)MA of randomized controlled trials (RCTs) in EDs. Systematic meta-review ((N)MA of RCTs, ED, active/inactive control), using (anorexia or bulimia or eating disorder) AND (meta-analy*) in PubMed/PsycINFO/Cochrane database up to December 15th, 2020. Standardized mean difference, odds/risk ratio vs control were summarized at end of treatment and follow-up. Interventions involving family (family-based therapy, FBT) outperformed active control in adults/adolescents with anorexia nervosa (AN), and in adolescents with bulimia nervosa (BN). In adults with BN, individual cognitive behavioural therapy (CBT)-ED had the broadest efficacy versus active control; also, antidepressants outperformed active. In mixed age groups with binge-eating disorder (BED), psychotherapy, and lisdexamfetamine outperformed active control. Antidepressants, stimulants outperformed placebo, despite lower acceptability, as did CBT-ED versus waitlist/no treatment. Family-based therapy is effective in AN and BN (adolescents). CBT-ED has the largest efficacy in BN (adults), followed by antidepressants, as well as psychotherapy in BED (mixed). Medications have short-term efficacy in BED (adults).
蒙泰莱奥内，A.M.，F. 佩莱格里诺，G. 克罗阿托，M. 卡尔法尼奥，A. 希尔伯特，J. 特雷西，T. 韦德，C. 布利克，S. 齐菲尔，P. 海，U. 施密特，G. 卡斯特利尼，A. 法瓦罗，F. 费尔南德斯-阿兰达，J. 伊尔·申，U. 沃德霍泽，V. 里卡，D. 莫雷蒂，D. 布萨塔，G. 阿巴泰-达加，F. 丘利尼，G. 卡斯奇诺，F. 莫纳科，C.U. 科雷尔，M. 索米。进食障碍的治疗：对荟萃分析和网络荟萃分析的系统综述。神经科学与生物行为评论 21(1)XXX-XXX，2022。- 进食障碍（ED）的治疗效果并不理想，治疗指南也存在差异。我们总结了进食障碍随机对照试验（RCT）的荟萃分析（网络）（N）MA 的发现/质量。采用系统的元综述（RCTs，ED，活性/非活性对照），在 PubMed/PsycINFO/Cochrane 数据库中使用（anorexia 或 bulimia 或 eating disorder）和（meta-analy*）进行搜索，时间截至 2020 年 12 月 15 日。在治疗结束和随访时，总结标准化均数差、优势比/风险比与对照组的关系。在青少年神经性厌食症（AN）和青少年神经性贪食症（BN）患者中，涉及家庭的干预措施（家庭为基础的治疗，FBT）优于活性对照；在 BN 成人患者中，个体认知行为治疗（CBT-ED）与活性对照相比具有最广泛的疗效；此外，抗抑郁药优于活性对照。在混合年龄组的暴食障碍（BED）患者中，心理治疗和 lisdexamfetamine 优于活性对照。抗抑郁药、兴奋剂优于安慰剂，尽管接受度较低，CBT-ED 也优于等待/不治疗。家庭为基础的治疗对 AN 和 BN（青少年）有效。在 BN（成人）中，CBT-ED 的疗效最大，其次是抗抑郁药，以及 BED（混合）中的心理治疗。药物在 BED（成人）中具有短期疗效。
