Metabolism of some ethylenediamine derivatives with antiarrhythmic properties. I. Absorption, distribution in tissues and excretion of 14-C labelled N, N'-bis-[3-(p-methoxyphenoxy)-2-hydroxypropyl]-ethylenediamine dimethanesulphonate (MK-142) in rats.

14-C labelled MK-142 (specific activity 2.875 muCi/mg) (1.762 mCi/mM) passes very rapidly from the blood stream to the majority of tissues since 5 min after the iv administration the blood contained only about 5% of the administered dose. The relatively high content of MK-142 in the myocardium as compared with its content in the skeletal muscles indicates a high affinity of the examined substance to the heart muscle. MK-142 is excreted via kidneys, alimentary tract and respiratory ways.