给大鼠口服制剂IF-ROM-196后的吸收、组织分布及排泄途径。
Absorption, distribution in tissues and routes of excretion of preparation IF-ROM-196 administered to rats orally.
作者信息
Nowicka A, Prussak T, Szukalski B
出版信息
Mater Med Pol. 1975 Oct-Dec;7(4):304-7.
PMID:1214517
Abstract
The metabolic fate of a new coronary vasodilating derivative of ethylenediamine (ROM--196) labeled with 14C has been studied in Wistar rats. Dynamics of absorption of the preparation, its distribution in tissues and excretion in urine, feces and bile and expiratory air were investigated. The preparation is quickly absorbed from the gastrointestinal tract and readily penetrates to the tissues. It is excreted mainly in the stools and urine.
摘要
在Wistar大鼠中研究了用14C标记的乙二胺新型冠状动脉扩张衍生物（ROM-196）的代谢命运。研究了该制剂的吸收动力学、在组织中的分布以及在尿液、粪便、胆汁和呼出气体中的排泄情况。该制剂可迅速从胃肠道吸收，并易于渗透到组织中。它主要通过粪便和尿液排泄。
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