Sakuta Manabu, Kumamoto Toshihide, Iizuka Takahiro, Nishiyama Kazutoshi, Oritsu Masaru
Department of Neurology, Kyorin University.
No To Shinkei. 2006 Jun;58(6):471-6.
We have collaborated with Japanese Sarcoidosis Society and Japanese Society of Respiratory Disease to provide a new diagnostic criteria of neurosarcoidosis. At least two of six examinations are important. These include bilateral hilar lymphadenopathy, abnormal uptake of 67Ga scintigraphy, broncho alveolar lavage fluid examination, elevated serum ACE, negative tuberculin reaction, and elevated serum or urinary calcium level. (definite) Having positive clinical findings which suggest a neurosarcoidosis. Pathology proven case. (probable) Having positive clinical findings which suggest a neurosarcoidosis. Pathology proven in other organ. At least two of six examinations are positive. (possible) Having positive clinical findings which suggest a neurosarcoidosis. At least two of six examinations are positive. CNS sarcoidosis, sarcoid neuroopathy and sarcoid myopathy are separately diagnosed. Kveim reaction which is time consuming, not so specific, and difficult to obtain its antigen is no more necessary.
我们与日本结节病协会及日本呼吸病学会合作,制定了神经结节病的新诊断标准。六项检查中至少两项很重要。这些检查包括双侧肺门淋巴结肿大、67Ga闪烁扫描摄取异常、支气管肺泡灌洗 fluid检查、血清ACE升高、结核菌素反应阴性以及血清或尿钙水平升高。(确诊)有提示神经结节病的阳性临床发现。病理证实病例。(很可能)有提示神经结节病的阳性临床发现。其他器官病理证实。六项检查中至少两项为阳性。(可能)有提示神经结节病的阳性临床发现。六项检查中至少两项为阳性。中枢神经系统结节病、结节性神经病和结节性肌病分别诊断。耗时、特异性不强且难以获取抗原的Kveim反应不再必要。 (注:原文中“broncho alveolar lavage fluid examination”中的“fluid”可能有误,推测应为“fluid examination”,翻译时按推测内容翻译了,若有误请按正确内容调整)