Iwasaki Hiroshi
Department of Anesthesiology and Critical Care, Asahikawa Medical College, Asahikawa 078-8510.
Masui. 2006 Jul;55(7):826-33.
For many years, much effort has been done to develop non-depolarizing neuromuscular blocking agents of rapid onset and short duration. It has been shown that rocuronium bromide is a nondepolarizing, steroidal muscle relaxant with fast onset and short-to-intermediate duration of action. In addition, rocuronium-induced neuromuscular blockade can be readily and consistently reversed following the administration of reversal agents. The pharmacology and pharmacodynamics of rocuronium bromide are summarized in this review.
多年来，人们付出了诸多努力来研发起效迅速且作用时间短暂的非去极化型神经肌肉阻滞剂。现已表明，罗库溴铵是一种非去极化型甾体类肌肉松弛剂，起效快，作用时间为短效至中效。此外，给予逆转剂后，罗库溴铵所致的神经肌肉阻滞能够迅速且持续地被逆转。本文综述了罗库溴铵的药理学和药效学。
