Banerjee Samar, Banerjee Mandira
Department of Medicine, Diabetic Clinic, NRS Medical College, Kolkata.
J Indian Med Assoc. 2006 Feb;104(2):86-9.
Hepatitis C virus infection in diabetes mellitus is more common than in non-diabetic population. Earlier it was thought to be due to more use of needles for insulin injections and frequent blood examination which has been recently antagonised by recent studies. Hepatitis C virus infection has shown to produce insulin resistance (because of liberated cytokines) insulin secretory defect (by viral infection or auto-immune damage). Hepatitis C virus infection also leads to non-alcoholic fatty liver disease (a probable component of insulin resistance syndrome) and increased iron increased iron storage in the body. All these factors may explain hepatitic C virus infection as an aetiology for diabetes mellitus. If future researches strongly establish this fact, antiviral or vaccines for hepatitis C virus infection should be thought of for preventing diabetes mellitus.
糖尿病患者中丙型肝炎病毒感染比非糖尿病人群更为常见。早期认为这是由于胰岛素注射使用针头更多以及频繁进行血液检查所致，不过近期研究对此提出了反对意见。丙型肝炎病毒感染已显示会产生胰岛素抵抗（由于释放的细胞因子）、胰岛素分泌缺陷（通过病毒感染或自身免疫损伤）。丙型肝炎病毒感染还会导致非酒精性脂肪性肝病（胰岛素抵抗综合征的一个可能组成部分）以及体内铁含量增加和铁储存增多。所有这些因素或许可以解释丙型肝炎病毒感染作为糖尿病病因的情况。如果未来研究有力地证实了这一事实，就应该考虑使用抗丙型肝炎病毒感染的药物或疫苗来预防糖尿病。
