Clínica Médica Sur, México, DF, México.
Salud Publica Mex. 2011;53 Suppl 1:S46-51.
Viral hepatitis is a common cause of morbidity in Mexico. Insulin resistance (IR) is related to the liver damage caused by some viral infections, especially chronic infections. Chronic viral infection is an important risk factor for the development of type 2 diabetes mellitus, disease that is currently among the 10 main causes of morbidity and the most common cause of mortality. Although several studies have reported an association between IR and hepatitis B virus or hepatitis C virus (HCV) infection, the pathophysiology has been studied thoroughly only for the association between IR and HCV infection. It is thought that HCV infection causes direct damage through the action of the core proteins, which induces an inflammatory state characterized by secretion of proinflammatory cytokines that interfere with normal insulin signaling and disturb glucose, lipid and protein metabolism. This review summarizes the mechanisms by which viral infection is thought to induce IR.
病毒性肝炎是墨西哥发病率的常见病因。胰岛素抵抗（IR）与某些病毒感染，尤其是慢性感染引起的肝损伤有关。慢性病毒感染是 2 型糖尿病发展的重要危险因素，这种疾病目前是发病率的前 10 大原因之一，也是最常见的死亡原因。尽管几项研究报告了 IR 与乙型肝炎病毒或丙型肝炎病毒（HCV）感染之间的关联，但仅对 IR 与 HCV 感染之间的关联进行了深入的病理生理学研究。据认为，HCV 感染通过核心蛋白的作用导致直接损伤，诱导以促炎细胞因子分泌为特征的炎症状态，这些细胞因子会干扰正常的胰岛素信号传导并扰乱葡萄糖、脂质和蛋白质代谢。这篇综述总结了病毒感染导致 IR 的机制。
