Bishop Anne E, Rippon Helen J
Imperial College Faculty of Medicine, Tissue Engineering & Regenerative Medicine Centre, Chelsea & Westminster Campus, Fulham Road, London, SW10 9NH, UK.
Expert Opin Biol Ther. 2006 Aug;6(8):751-8. doi: 10.1517/14712598.6.8.751.
Repair or regeneration of defective lung epithelium would be of great therapeutic potential. It is estimated by the British Lung Foundation that 1 in 7 people in the UK is affected by a lung disease and that 1 in 4 admissions to children's wards are as a result of respiratory problems. Potential cellular sources for the regeneration of lung tissue in vivo or lung tissue engineering in vitro include endogenous pulmonary epithelial stem cells, extrapulmonary circulating stem cells and embryonic stem cells. This article discusses the potential role of each of these stem cell types in future approaches to the treatment of lung injury and disease.
修复或再生有缺陷的肺上皮具有巨大的治疗潜力。英国肺部基金会估计，英国每7人中就有1人受肺部疾病影响，且儿童病房中四分之一的住院病例是由呼吸问题导致的。体内肺组织再生或体外肺组织工程的潜在细胞来源包括内源性肺上皮干细胞、肺外循环干细胞和胚胎干细胞。本文讨论了每种干细胞类型在未来治疗肺损伤和疾病方法中的潜在作用。
