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[双链DNA断裂在减数分裂机制中的作用]

[The role of double-stranded DNA breaks in the mechanism of meiosis].

作者信息

Gershenzon S M

出版信息

Tsitol Genet. 1994 Jan-Feb;28(1):83-9.

PMID:8066819
Abstract

A review is given of recent publications devoted to the investigation of molecular mechanisms of meiosis. It is stated that double-strand breaks of chromosomal DNA, which can be successfully repaired during meiosis, are also the cause of meiotic conjugation of homologous chromosomes and of their genetic recombination (crossing-over). Arguments are presented that meiosis had historically arisen from the reparation of double-strands breaks of DNA during mitosis.

摘要

本文综述了近期有关减数分裂分子机制研究的出版物。文中指出,染色体DNA的双链断裂在减数分裂过程中能够成功修复,同时也是同源染色体减数分裂配对及其基因重组(交叉互换)的原因。文中还提出了相关论据,即减数分裂在历史上起源于有丝分裂过程中DNA双链断裂的修复。

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